Combination of Maca Colors

Summary of Findings:

Taking a Concentrated Gelatinized Proprietary Phenotype Formulation of maca, known as MacaHarmony, the following results were achieved within 3 months:

1. Normalization of menstrual frequency (28-32 days)

2. Resolution of ovulation pain and cramping

3. Improved ovulation as evidenced by increased cervical mucus and libido

4. Decreased/resolved PMS duration and intensity of symptoms

5. Decreased menstrual blood flow and improved quality of menstrual blood (bright red vs. brown)

6. Decreased menstrual cramping (intensity, duration, and location)

Additionally, a comparative analysis of biomarkers revealed:

Hormone balancing as evidenced by a reduction of LH, normalization of LH/FSH ratio, and a reduction in E2 to optimal levels for fertility.

Summary of Results:

Case report using a proprietary formulation of Lepidium peruvianum (MacaHarmony), 500 mg twice daily

Resolution of multiple PMS symptoms, including:

1. Balanced moods

2. Improved satiety

3. Reduced cystic acne

4. Regulated bowel movements

5. Resolution of menstrual pain and cramping (dysmenorrhea)

6. Lighter menstrual cycles

Summary of Findings

Case report using a proprietary formulation of Lepidium peruvianum (MacaHarmony), 500 mg twice daily. Bio-identical progesterone and magnesium supplementation was also used

Results

1. Resolution of premenstrual headaches in three months

2. Decreased menstrual cramping and reduced blood flow in three months

3. Resolution of intense psychiatric symptoms associated with a diagnosis of PMDD in three months

4. Normalization of LH levels was achieved in four months

Summary of Findings

Case report, surgically-induced menopause, 1,000 mg twice daily of a combination product known as Maca-GO

1. Resolution of hot flashes and anxiety in 2 months

2. Improved mood and sleep

Summary of Findings:

A hydroalcoholic extract of a combination of maca colors (red, black, and yellow), known as MACAXS, was fed to male rats for 6 weeks. 

1. The combination maca extract resulted in an increase in serum testosterone concentration.

Summary of Findings:

Two trials were conducted using a combination product known as Maca-GO, 1000 mg twice daily

Trial 1: N=22

1. Significant decrease in BMI and LH levels (p<0.05)

2. Significant increase in E2 (P<0.05)

3. Significant reductions in T3, cortisol, ACTH (p<0.05)

4. Significant increase in serum iron and plasma calcium levels (p<0.05)

5. Significant decrease in menopausal symptoms (p<0.001)

Trial 2: N=12

1. Increase in forearm bone density in 4 months, whereas the placebo group had a reduction in bone density during the same time.  

2. Maca group had increase in E2 and decrease in FSH.

Summary of Findings:

Two trials were conducted using a combination product known as Maca-GO, 1000 mg twice daily

Trial 1: N=102

1. Significant increase in E2 (P<0.001)

2. Significant decrease in FSH (p<0.05)

3. Significant increase in HDL levels (p<0.05)

4. Significant decrease in menopausal symptoms in one month (p<0.001) of treatment and further reduction in the second months of treatments, followed by an increase of symptoms when returning to placebo (p<0.001)

Trial 2: N=66

1. Significant decrease in FSH and LH (p<0.05),

2. Significant increase in E2 (p<0.05)

3. Significant reduction in menopausal symptoms (p<0.001)

Summary of Findings:

The study used a combination formulation known as Maca-GO with the aim of the study to determine toxicity of and to assess various effects of Maca-GO systemically. 

1. The toxicity was > 15 g/kg of body weight in mice and > 5 g/kg body weight in rats, a dose much higher than would be administered in humans and would be classified as non-toxic.

2. In rats with functioning ovaries and after ovariectomy, a reduction in estradiol and progesterone levels were observed. 

3. Maca-GO provided anti-depressant effects, improvements in cognitive function, reductions in cortisol, ACTH, total cholesterol, and triglycerides.

Summary of Findings:

Women took 1000 mg twice daily of a combination product called Maca-GO for 2 months.

1. 95% of women involved in the study had improvements in menopausal symptoms as assessed by Kupperman’s Menopausal Index

2. Significant reduction in menopausal symptoms: hot flashes, excessive sweating, interrupted sleep (all at p<0.01), nervousness, depression, heart palpitations (p<0.05)

3. Significant reduction in body weight, systolic and diastolic blood pressure (p<0.05)

4. Significant increase in HDL (p<0.01) and iron (p<0.05) levels

5. Significant increase in E2, FSH, and PG (p<0.01)

6. Significant reduction in ACTH (p<0.05)

Summary of Findings:

A combination of maca colors known as Maca-GO was given to male and female rats in two different doses (0.75 g/kg (low dose) and 7.5 g/kg (high dose) body weight)

1. Significant reduction on body weight for male rats (p<0.001) at the high dose

2. Significant decrease in cortisol levels (p<0.001) with the low dose

3. Significant decrease in cortisol levels (p<0.01), triglycerides (p<0.05) with the high dose

4. Significant increase in estradiol levels (p<0.01) with the high dose. 

5. Long term use (90 days) of the high dose of Maca-GO resulted in increased in blood glucose and progesterone levels. 

Summary of Findings:

A dose of 1000 mg twice daily of a combination product known as Maca-GO was taken for 2 or 8 months, with 1 month of a placebo.

At 2 and 8 months:

1. Significant decrease in FSH (P<0.05)

2. Significant increase in LH (P<0.05)

3. Significant reduction in menopausal symptoms in 2 and 8 months (p<0.05) 

At month 8

1. Significant increase in E2 and PG (P<0.05)