Cardiometabolic Health
At present, there is limited but promising evidence that select maca phenotypes can favorably impact various markers of cardiometabolic health.
Animal Studies
An animal study using an aqueous extract of black maca (AEM) in golden hamsters identified 32 bioactive compounds of black maca that target 16 proteins involved in metabolism disorders. Of its benefits, AEM promoted glycolysis, inhibited gluconeogenesis, enhanced beta-oxidation, and upregulated tricarboxylic acid cycle. Lipid-lowering effects were also observed, including enhanced fatty acid oxidation and lipogenesis pathway inhibition. During this 20-week study, hamsters were fed a high-fat, high-fructose diet and were given AEM in a dose of 300, 600, or 1,200 mg/kg body weight. As the body weight, liver weight, and fat weight did not increase, it is suggested that black maca accelerated the metabolism of the animals. Additionally, at the higher doses (600 and 1,200 mg/kg), serum total cholesterol, triglycerides, LDL-cholesterol, and insulin decreased (1).
To explore metabolic impact, a black-red maca (4:1 ratio) powder was administered for 60 days to rats as a standalone therapy or in combination with a high fat diet. Maca supplementation provided a significant increase in leptin levels (p<0.01), insulin receptor substrate-1 (IRS1) (p<0.0001), and SIRT1 levels (p<0.01) in fat and liver tissue, while fat tissue and insulin levels decreased (p<0.001) suggesting its potential role to aid in the regulation of energy metabolism and a possible agent for obesity medicine (2).
Similarly, in 4 weeks, maca significantly decreased blood glucose and lipid levels, improved liver function and insulin resistance, and reduced inflammation in rats, suggesting its role to aid in the management of type 2 diabetes and metabolic syndrome (3).
Streptozotocin-induced diabetic mice were given black maca, yacon (a Peruvian plant), or one of three mixtures of a black maca/yacon extract (90/10, 50/50, or 10/90%). Each of the treatments significantly reduced glucose levels in diabetic mice, with the best effects observed in the 90/10 and 10/90% mixture of black maca/yacon. The authors propose quercetin, a polyphenol in maca, acts as a peroxisome proliferator-activated receptor (PPAR) agonist, which may reduce hyperglycemia, though they also attribute other phytochemicals to its benefits (i.e., beta-sitosterol). Black maca did not impact glycemia in animals with normal glucose levels (4).
Human Studies
A randomized, double-blind, placebo-controlled trial of 175 participants was conducted for 12 weeks. Participants lived in either the low-altitude (LA) or high-altitude (HA) regions of Peru. They took 3 grams of black or red maca extract. Both black and red maca reduced blood glucose levels by eight weeks (p<0.05 and p<0.01, respectively), and levels remained decreased at week 12. Systolic blood pressure was reduced in weeks 8 and 12 in the HA group only, using black maca (p<0.01). Other health benefits were also observed, including improved energy and mood (5).
A significant decrease in systolic (p=0.05) and diastolic (p=0.01) blood pressure was observed in postmenopausal women using 3.3 grams per day of an unspecified color of maca for six weeks, though no differences in glucose or lipids were achieved (6). Similarly, systolic blood pressure was lower in men and women who regularly consumed maca as a food source compared to those who did not. (7)
A significant increase (p<0.05) of HDL-cholesterol was observed in early postmenopausal women seen using a proprietary formulation of Lepidium peruvianum, known as Maca-GO, when compared to placebo (8). In perimenopausal women, Maca-GO significantly improved HDL-cholesterol (p<0.01) and produced a significant reduction in systolic and diastolic blood pressure and BMI (p<0.05) (9). Both studies achieved these results in two months using a dose of 1,000 mg twice daily.
Further, black maca has been shown to provide improvements to markers that can impact cardiometabolic health, such as lowering select inflammatory markers (C-reactive protein, IL-6, and TNF alpha) (10,11), decreasing BMI (12), and improving cardiopulmonary endurance (10), though each of these studies included athletes for the population studied.
Of interest, in a cell study, fermented maca resulted in a 4.3-fold increase in total cholesterol binding capacities compared to non-fermented maca. The authors attribute the increase of saponin content as the potential mechanism of action (13).
Author: Mona Fahoum, ND
Reviewer: Kim Ross, DCN
Last Updated: December 17, 2024
References
1. Wan W, Li H, Xiang J, Yi F, Xu L, Jiang B, et al. Aqueous Extract of Black Maca Prevents Metabolism Disorder via Regulating the Glycolysis/Gluconeogenesis-TCA Cycle and PPARα Signaling Activation in Golden Hamsters Fed a High-Fat, High-Fructose Diet. Front Pharmacol. 2018;9:333.
2. Gencoglu H. Maca modulates fat and liver energy metabolism markers insulin, IRS1, leptin, and SIRT1 in rats fed normal and high-fat diets. Arch Physiol Biochem. 2023;129(2).
3.Mohamed SM, Shalaby MA, El-Shiekh RA, Bakr AF, Kamel S, Emam SR, et al. Maca roots: A potential therapeutic in the management of metabolic disorders through the modulation of metabolic biochemical markers in rats fed high-fat high-carbohydrate diet. J Ethnopharmacol. 2024;321.
4. Gonzales GF, Gonzales-Castañeda C, Gasco M. A mixture of extracts from Peruvian plants (black maca and yacon) improves sperm count and reduced glycemia in mice with streptozotocin-induced diabetes. Toxicol Mech Methods. 2013;23(7).
5. Gonzales-Arimborgo C, Yupanqui I, Montero E, Alarcón-Yaquetto DE, Zevallos-Concha A, Caballero L, et al. Acceptability, Safety, and Efficacy of Oral Administration of Extracts of Black or Red Maca (Lepidium meyenii) in Adult Human Subjects: A Randomized, Double-Blind, Placebo-Controlled Study. Pharmaceuticals (Basel). 2016 Aug 18;9(3).
6. Stojanovska L, Law C, Lai B, Chung T, Nelson K, Day S, et al. Maca reduces blood pressure and depression, in a pilot study in postmenopausal women. Climacteric. 2015;18(1).
7. Gonzales GF, Gasco M, Lozada-Requena I. Role of Maca (Lepidium meyenii) Consumption on Serum Interleukin-6 Levels and Health Status in Populations Living in the Peruvian Central Andes over 4000 m of Altitude. Plant Foods for Human Nutrition. 2013;68(4).
8. Meissner, HO Mscisz, A Bilinska-Reich, H, Kapczynski, W, Mrozikiewicz, P Bobkiewicz-Kozlowska, T Kedzia, B Lowicka, A Barchia I. Hormone-Balancing Effect of Pre-Gelatinized Organic Maca (Lepidium peruvianum Chacon): (II) Physiological and Symptomatic Responses of Early-Postmenopausal Women to Standardized doses of Maca in Double Blind, Randomized, Placebo-Controlled, Multi-Centre C. Int J Biomed Sci. 2006;2(4):360–74.
9. Meissner HO, Reich-Bilinska H, Mscisz A, Kedzia B. Therapeutic Effects of Pre-Gelatinized Maca (Lepidium Peruvianum Chacon) used as a Non-Hormonal Alternative to HRT in Perimenopausal Women - Clinical Pilot Study. Int J Biomed Sci. 2006;
10. Lee E, Park M, Kim B, Kang S. Effect of Black Maca Supplementation on Inflammatory Markers and Physical Fitness in Male Elite Athletes. Nutrients. 2023;15(7).
11. Choi JW, Kang S. Effect of Intake Black Maca on Inflammatory Factors in Female Athletics. Journal of Sport and Dance Science. 2021 Dec 31;1(2):39–47.
12. Kang S, Ahn BO, Park MH, Lim ST, Lee E. Effects of Black Maca supplement on isokinetics muscular performance of elite women’s handball players: placebo-controlled, crossover study. Food Nutr Res. 2023;67.
13. Ryu KM, Kim H, Woo J, Lim J, Kang CG, Kim SW, et al. Enhancement of the bioactive compounds and biological activities of maca (Lepidium meyenii) via solid-state fermentation with Rhizopus oligosporus. Food Sci Biotechnol. 2024;33(11).